IVI investigators have developed the most complete and advanced test in the market. Its name is GCT (Genetic compatibility test) and it detects gentic pathologies of the future baby before the pregnancy.
“Currently the diseases caused by specific gene alteration are present in 1 out of 300 newly-borns. Our objective with this new test that includes a wide range of mutations is to reduce significantly the risk of a couple to have descendents with any genetic disease”, Antonio Requena explains who is the medical director of IVI Group. Every healthy person is a carrier of 6 to 15 genetic alterations. In specific cases it is possible to detect the genetic diseases carried by a father, a mother or by both of them after a baby is born. The test for genetic compatibility includes the narrowing down of all mutations recommended by the gynecology and genetics professional associations, and it includes a wide range of mutations that lead to hereditary disease caused by 552 genes. The most often out of them are cystic fibrosis, muscular spine atrophy and renal polycystosis.
“For that reason it is important to prevent this type of diseases knowing the alterations that each couple member presents, evaluating the dominants and checking that there are coincidences in a way that the risk of having a sick child (50% in dominants, 25% in recessives genes) look reduced. The use of these tests helps to reduce the alterations in the descendents of 1 out of 300 new-borns to 1 out of 30K-40K”, Requena adds.
The procedure consists of a simple blood extraction from the parents that helps to describe the DNA sequence and that is used to conduct PCR quantitative analysis (polymerase chain reaction) for altered genes, massive sequencing of important regions of almost 600 genes where the majority of known mutations is localized. And finally bioinformation analysis is conducted for the sequencing results, with the posterior filter of all encountered versions, which will be used to determine mutation candidates.
GCT test in assisted reproduction patients
GCT test shall be done in context of the cases with assisted reproduction patients in relation to the treatments that they get, since it does not go in the same way when it is about own gametes and gamete donation. In first case, the couple that shows positive in the same gene will have the option to undergo the preimplantation genetic diagnosis (PGD) before the embryo implantation to ensure that the baby will be born free from hereditary diseases.
When a couple uses gamete donation, both or only one of them, the analysis system includes the test for genetic compatibility that impedes the crossing of gametes with a risk for the same gene and avoids the baby getting born with a pathology.
“GCT permits analyzing multiple genes or mutations simultaneously and cost effectively and for the first time it is possible to establish the narrowing programs for a large number of monogenic diseases or serious diseases caused by gen alteration. This way we can prevent the appearance of a disease both in naturally conceived pregnancies or gestated using assisted reproduction techniques”, the doctor concludes.
28 Jul 2014